HSV-TK substrate

• Description :

  HSV-TK substrate is a substrate for HSV-TK, and induces multi-log cytotoxicity in HSV-TK-expressing and bystander cells. HSV-TK substrate shows antitumor activity[1].

• CAS Number :

  [111687-37-7]

• UNSPSC :

  12352005

• Target :

  HSV

• Type :

  Reference compound

• Related Pathways :

  Anti-infection

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/hsv-tk-substrate.html

• Solubility :

  10 mM in DMSO

• Smiles :

  O=C1NC(N)=NC2=C1N=CN2[C@H]3[C@H](O)[C@H](O)[C@@H](CO)C3

• Molecular Formula :

  C11H15N5O4

• Molecular Weight :

  281.27

• References & Citations :

  [1]Shewach DS, et al. Multi-log cytotoxicity of carbocyclic 2'-deoxyguanosine in HSV-TK-expressing human tumor cells. Hum Gene Ther. 2002 Mar 1;13 (4) :543-51.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported