S1PR1 modulator 1

• Description:

  S1PR1 modulator 1 is a selective S1PR1 inhibitor, with a pIC50 of 7.6, with >40- and >80-fold selectivity, over the other S1PR isoforms S1PR2/3/4[1].

• UNSPSC:

  12352005

• Target:

  LPL Receptor

• Type:

  Reference compound

• Related Pathways:

  GPCR/G Protein

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Inflammation/Immunology

• Assay Protocol:

  https://www.medchemexpress.com/s1pr1-modulator-1.html

• Purity:

  99.52

• Solubility:

  DMSO : 62.5 mg/mL (ultrasonic; warming)

• Smiles:

  CC1=CC=CC=C1N2C(/C(S/C2=N\CCC)=C/C3=CC=C(OC(C)=O)C(C)=C3)=O

• Molecular Formula:

  C23H24N2O3S

• Molecular Weight:

  408.51

• References & Citations:

  [1]Bell M, et al. Discovery of Soft-Drug Topical Tool Modulators of Sphingosine-1-phosphate Receptor 1 (S1PR1) . ACS Med Chem Lett. 2019 Feb 14;10 (3) :341-347.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [2328109-05-1]