NR1H4 activator 1

• UNSPSC Description:

  NR1H4 activator 1 is a potent and selective Famesoid X Receptor (FXR) agonist, extracted from patent WO2018152171A1, example 4. NR1H4 activator 1 shows strong FXR agonistic potency with a EC50 value of 1 nM in a Human FXR (NR1H4) Assay. NR1H4 activator 1 has the potential for treatment of gastrointestinal disease[1].

• Target Antigen:

  FXR

• Type:

  Reference compound

• Related Pathways:

  Metabolic Enzyme/Protease

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Inflammation/Immunology

• Assay Protocol:

  https://www.medchemexpress.com/nr1h4-activator-1.html

• Solubility:

  10 mM in DMSO

• Smiles:

  C[C@@]12[C@@H]([C@H](C)COC(NS(=O)(C3=CC=C(OC(C)C)C=C3)=O)=O)CC[C@@]1([H])[C@]4([H])[C@H](O)[C@H](CC)[C@]5([H])C[C@@H](O)CC[C@]5(C)[C@@]4([H])CC2

• Molecular Weight:

  619.85

• References & Citations:

  [1]Guoqiang Wang, et al. Bile acid derivatives as fxr agonists and methods of use thereof. Patent WO2018152171A1.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  2242855-68-9