NR1H4 activator 1

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804-HY-125996

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CAS Number: 2242855-68-9
UNSPSC Description: NR1H4 activator 1 is a potent and selective Famesoid X Receptor (FXR) agonist, extracted from patent WO2018152171A1, example 4. NR1H4 activator 1 shows strong FXR agonistic potency with a EC50 value of 1 nM in a Human FXR (NR1H4) Assay. NR1H4 activator 1 has the potential for treatment of gastrointestinal disease[1].
Target Antigen: FXR
Type: Reference compound
Related Pathways: Metabolic Enzyme/Protease
Applications: COVID-19-immunoregulation
Field of Research: Inflammation/Immunology
Assay Protocol: https://www.medchemexpress.com/nr1h4-activator-1.html
Solubility: 10 mM in DMSO
Smiles: C[C@@]12[C@@H]([C@H](C)COC(NS(=O)(C3=CC=C(OC(C)C)C=C3)=O)=O)CC[C@@]1([H])[C@]4([H])[C@H](O)[C@H](CC)[C@]5([H])C[C@@H](O)CC[C@]5(C)[C@@]4([H])CC2
Molecular Weight: 619.85
References & Citations: [1]Guoqiang Wang, et al. Bile acid derivatives as fxr agonists and methods of use thereof. Patent WO2018152171A1.
Shipping Conditions: Room temperature
Clinical Information: No Development Reported

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