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MTH1 activator-1

CAT: 0804-HY-171230-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-171230-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
MTH1 activator-1 is an MTH1 activator that enhances endogenous MTH1 activity and significantly reduces 8-oxo-dG levels in cellular DNA. MTH1 activator-1 can be used to probe the cellular and biological effects of upregulated oxidative damage repair in nucleotide pools and to delay or abrogate tumorigenesis[1].
CAS Number
2803422-60-6
UNSPSC
12352005
Target
DNA/RNA Synthesis
Related Pathways
Cell Cycle/DNA Damage
Field of Research
Cancer
Purity
98.18
Smiles
O=C(C1=NC=C(C=C1)C#CC2=CC=CC3=C2C=CN=C3)NC4=CC=C(CN5CCOCC5)C(C(F)(F)F)=C4
Molecular Formula
C29H23F3N4O2
Molecular Weight
516.51
References & Citations
[1]Lee Y, et al. Enhancing Repair of Oxidative DNA Damage with Small-Molecule Activators of MTH1. ACS Chem Biol. 2022 Aug 19;17 (8) :2074-2087.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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