MTH1 activator-1

• Description:

  MTH1 activator-1 is an MTH1 activator that enhances endogenous MTH1 activity and significantly reduces 8-oxo-dG levels in cellular DNA. MTH1 activator-1 can be used to probe the cellular and biological effects of upregulated oxidative damage repair in nucleotide pools and to delay or abrogate tumorigenesis[1].

• UNSPSC:

  12352005

• Target:

  DNA/RNA Synthesis

• Related Pathways:

  Cell Cycle/DNA Damage

• Field of Research:

  Cancer

• Purity:

  98.18

• Smiles:

  O=C(C1=NC=C(C=C1)C#CC2=CC=CC3=C2C=CN=C3)NC4=CC=C(CN5CCOCC5)C(C(F)(F)F)=C4

• Molecular Formula:

  C29H23F3N4O2

• Molecular Weight:

  516.51

• References & Citations:

  [1]Lee Y, et al. Enhancing Repair of Oxidative DNA Damage with Small-Molecule Activators of MTH1. ACS Chem Biol. 2022 Aug 19;17 (8) :2074-2087.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [2803422-60-6]