MGluR1 activator-1

• Description:

  MGluR1 activator-1 is a stable Vitamin K (HY-B2172) analogue and a mGluR1 activator that can penetrate the blood-brain barrier. mGluR1 activator-1 exhibits strong transcriptional activation via steroid and xenobiotic receptor as well as retinoic acid receptor. mGluR1 activator-1 induces neuronal differentiation in mouse neural progenitor cells. mGluR1 activator-1 can be used for the study of neurodegenerative disease such as Alzheimer’s[1].

• UNSPSC:

  12352005

• Target:

  MGluR; Steroid Sulfatase

• Related Pathways:

  GPCR/G Protein; Metabolic Enzyme/Protease; Neuronal Signaling

• Applications:

  Neuroscience-Neurodegeneration

• Field of Research:

  Neurological Disease

• Smiles:

  O=C(/C(C)=C/C=C/C(C)=C/CC/C(C)=C/CC1=C(C(C2=C(C1=O)C=CC=C2)=O)C)OC

• Molecular Formula:

  C27H30O4

• Molecular Weight:

  418.52

• References & Citations:

  [1]Hirota Y, et al. A New Class of Vitamin K Analogues Containing the Side Chain of Retinoic Acid Have Enhanced Activity for Inducing Neuronal Differentiation. ACS Chem Neurosci. 2025 Jul 3.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  MGluR1