4'-Ethynyl-2'-deoxyadenosine

4'-Ethynyl-2'-deoxyadenosine

• CAS Number: 306305-07-7
• UNSPSC Description: 4'-Ethynyl-2'-deoxyadenosine (4'-E-dA), a nucleoside reverse transcriptase (RT) inhibitor, is an antiretroviral agent which is potent against drug-resistant HIV variants, with an EC50 of 98 nM in MT-4 cells for anti-HIV-1 activity[1]. 4'-Ethynyl-2'-deoxyadenosine is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
• Target Antigen: HIV; Reverse Transcriptase
• Type: Reference compound
• Related Pathways: Anti-infection
• Applications: COVID-19-anti-virus
• Field of Research: Infection; Inflammation/Immunology
• Assay Protocol: https://www.medchemexpress.com/4-ethynyl-2-deoxyadenosine.html
• Solubility: 10 mM in DMSO
• Smiles: OC[C@]1(C#C)[C@H](C[C@H](N2C=NC3=C(N=CN=C32)N)O1)O
• Molecular Weight: 275.26
• References & Citations: [1]Ohrui H, et al. 4'-C-substituted-2'-deoxynucleosides: a family of antiretroviral agents which are potent against drug-resistant HIV variants. Curr Drug Targets Infect Disord. 2001 May;1(1):1-10.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported