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4'-Ethynyl-2'-deoxyadenosine

CAT: 0804-HY-125810Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-125810Size:1 Each
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Description
4'-Ethynyl-2'-deoxyadenosine (4'-E-dA), a nucleoside reverse transcriptase (RT) inhibitor, is an antiretroviral agent which is potent against drug-resistant HIV variants, with an EC50 of 98 nM in MT-4 cells for anti-HIV-1 activity[1]. 4'-Ethynyl-2'-deoxyadenosine is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
CAS Number
306305-07-7
UNSPSC
12352005
Target
HIV; Reverse Transcriptase
Type
Reference compound
Related Pathways
Anti-infection
Applications
COVID-19-anti-virus
Field of Research
Infection; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/4-ethynyl-2-deoxyadenosine.html
Solubility
10 mM in DMSO
Smiles
OC[C@]1(C#C)[C@H](C[C@H](N2C=NC3=C(N=CN=C32)N)O1)O
Molecular Formula
C12H13N5O3
Molecular Weight
275.26
References & Citations
[1]Ohrui H, et al. 4'-C-substituted-2'-deoxynucleosides: a family of antiretroviral agents which are potent against drug-resistant HIV variants. Curr Drug Targets Infect Disord. 2001 May;1 (1) :1-10.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
HIV-1

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