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2’-Chloro-2’-deoxyadenosine

CAT: 0804-HY-152334-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-152334-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
2’-Chloro-2’-deoxyadenosine is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].
CAS Number
2627-62-5
UNSPSC
12352005
Target
Nucleoside Antimetabolite/Analog
Type
Oligonucleotides
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/2-chloro-2-deoxyadenosine.html
Purity
98.53
Solubility
DMSO : ≥ 100 mg/mL
Smiles
O[C@H]1[C@@H](Cl)[C@H](N2C(N=CN=C3N)=C3N=C2)O[C@@H]1CO
Molecular Formula
C10H12ClN5O3
Molecular Weight
285.69
References & Citations
[1]Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18 (23) :3373-88.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Oligonucleotides
Clinical Information
No Development Reported

Chemical Information

2'-Chloro-2'-deoxyadenosine
CAS Number2627-62-5
PubChem CID100327
IUPAC Name(2R,3R,4R,5R)-5-(6-aminopurin-9-yl)-4-chloro-2-(hydroxymethyl)oxolan-3-ol
Molecular FormulaC10H12ClN5O3
Molecular Weight285.69
XLogP0.2
Topological Polar Surface Area119
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count7
Rotatable Bond Count2
Heavy Atom Count19
Formal Charge0
Complexity338
SMILES
C1=NC(=C2C(=N1)N(C=N2)[C@H]3[C@@H]([C@@H]([C@H](O3)CO)O)Cl)N
InChI
InChI=1S/C10H12ClN5O3/c11-5-7(18)4(1-17)19-10(5)16-3-15-6-8(12)13-2-14-9(6)16/h2-5,7,10,17-18H,1H2,(H2,12,13,14)/t4-,5-,7-,10-/m1/s1
InChIKey
ADXUXRNLBYKGOA-QYYRPYCUSA-N
Chemical Structure
2D Structure
2D structure of 2'-Chloro-2'-deoxyadenosine
CAS: 2627-62-5
CID: 100327
Formula: C10H12ClN5O3
MW: 285.69
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight285.69
XLogP30.2
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count7
Rotatable Bond Count2
Exact Mass285.0628670
Monoisotopic Mass285.0628670
Topological Polar Surface Area119 Ų
Heavy Atom Count19
Formal Charge0
Complexity338
Isotope Atom Count0
Defined Atom Stereocenter Count4
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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