RegisterLogin

2'-Deoxyadenosine

CAT: 0804-HY-W040329-01Size: 100 mgDry Ice: NoHazardous: No
CAT#:0804-HY-W040329-01Size:100 mg
Selected
PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
Description
2′-Deoxyadenosine is an adenine nucleoside that inhibits glucose-stimulated insulin release. 2′-Deoxyadenosine inhibits glucose-stimulated increases seen in islet cyclic AMP (cAMP) accumulation. 2'-Deoxyadenosine activates caspase-3 and promotes apoptosis. 2'-Deoxyadenosine inhibits the activity of S-adenosyl-L-homocysteine hydrolase (SAHH) . 2'-Deoxyadenosine inhibits the growth of various cells. 2'-Deoxyadenosine has an anticancer effect on colon cancer[1][2][3].
CAS Number
[958-09-8]
UNSPSC
12352005
Hazard Statement
H301
Target
Apoptosis; Caspase; Endogenous Metabolite; Nucleoside Antimetabolite/Analog
Type
Natural Products
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Metabolic Enzyme/Protease
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Cancer; Endocrinology; Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/_2R,3S,5R_-5-_6-Amino-9H-purin-9-yl_-2-_hydroxymethyl_tetrahydrofuran-3-ol.html
Purity
99.99
Solubility
DMSO : 100 mg/mL (ultrasonic) |H2O : 16.67 mg/mL (ultrasonic)
Smiles
NC1=NC=NC2=C1N=CN2[C@H]3C[C@H](O)[C@@H](CO)O3
Molecular Formula
C10H13N5O3
Molecular Weight
251.25
Precautions
H301
References & Citations
[1]Giannecchini M, et al. 2'-Deoxyadenosine causes apoptotic cell death in a human colon carcinoma cell line. J Biochem Mol Toxicol. 2003;17 (6) :329-37.|[2]Cass CE, et al. Effects of 2'-deoxyadenosine, 9-beta-D-arabinofuranosyladenine, and related compounds on S-adenosyl-L-homocysteine hydrolase activity in synchronous and asynchronous cultured cells. Cancer Res. 1982 Dec;42 (12) :4991-8.|[3]Iizuka H, et al. Effects of adenosine and 2'-deoxyadenosine on epidermal keratinocyte proliferation: its relation to cyclic AMP formation. J Invest Dermatol. 1984 Jun;82 (6) :608-12.|[4]Bemi V, et al. Deoxyadenosine metabolism in a human colon-carcinoma cell line (LoVo) in relation to its cytotoxic effect in combination with deoxycoformycin. Int J Cancer. 1998 Mar 2;75 (5) :713-20.|[5]Wakade AR, et al. 2'-deoxyadenosine induces apoptosis in rat chromaffin cells. J Neurochem. 1996 Dec;67 (6) :2273-81.|[6]Gao X, et al. Activation of apoptosis in early mouse embryos by 2'-deoxyadenosine exposure. Teratology. 1994 Jan;49 (1) :1-12. |[7]Kuttesch JF Jr, et al. Renal handling of 2'-deoxyadenosine and adenosine in humans and mice. Cancer Chemother Pharmacol. 1982;8 (2) :221-9. |[8]Iain L. Campbell, et al. Effects of adenosine, 2-deoxyadenosine and N6-phenylisopropyladenosine on rat islet function and metabolism. Biochem J (1982) 204 (3) : 689-696.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
Human Endogenous Metabolite

Related Products

CatalogName
HY-1545202-Chloro-3′-deoxyadenosine
HY-113291-015'-Deoxyadenosine
HY-113291R5'-Deoxyadenosine (Standard)
HY-W552525-01Deoxyadenosine diphosphate (sodium)
HY-1645573′-Deoxyadenosine 5′-triphosphate
HY-1318023'-Azido-3'-deoxyadenosine
HY-1382273′-Deoxyadenosine 5′-diphosphate
HY-W616732-015′-Fluoro-5′-deoxyadenosine
HY-131790-013'-Amino-3'-deoxyadenosine
HY-131818-015'-Amino-5'-deoxyadenosine

Alternative Products

CatalogName
TRC-D239583-5G2’-Deoxyadenosine
sc-275525A2'-Deoxyadenosine
B7860-1002-Deoxyadenosine
MBS657833-012'-Deoxyadenosine Monohydrate
421117-012'-Deoxyadenosine-15N1
GN7468-5g2''-Deoxyadenosine monohydrate
DD00432'-Deoxyadenosine, monohydrate
Tc1111-012-Deoxyadenosine Monohydrate

Popular Products