2'-Deoxyadenosine monohydrate

2′-Deoxyadenosine monohydrate is an adenine nucleoside that inhibits glucose-stimulated insulin release. 2′-Deoxyadenosine monohydrate inhibits glucose-stimulated increases seen in islet cyclic AMP (cAMP) accumulation. 2'-Deoxyadenosine monohydrate activates caspase-3 and promotes apoptosis. 2'-Deoxyadenosine monohydrate inhibits the activity of S-adenosyl-L-homocysteine hydrolase (SAHH) . 2'-Deoxyadenosine monohydrate inhibits the growth of various cells. 2'-Deoxyadenosine monohydrate has an anticancer effect on colon cancer[1][2][3].

16373-93-6

12352005

H301

Apoptosis; Caspase; Endogenous Metabolite; Nucleoside Antimetabolite/Analog

Natural Products

Apoptosis; Cell Cycle/DNA Damage; Metabolic Enzyme/Protease

Metabolism-protein/nucleotide metabolism

Cancer; Endocrinology; Metabolic Disease

https://www.medchemexpress.com/2_acute_-Deoxyadenosine_monohydrate.html

99.89

DMSO : 50 mg/mL (ultrasonic) |H2O : 7.14 mg/mL (ultrasonic; warming; heat to 60°C)

O[C@H]1C[C@H](N2C(N=CN=C3N)=C3N=C2)O[C@@H]1CO.O

C10H15N5O4

269.26

H301

[1]Iain L. Campbell, et al. Effects of adenosine, 2-deoxyadenosine and N6-phenylisopropyladenosine on rat islet function and metabolism. Biochem J (1982) 204 (3) : 689-696.|[2]Giannecchini M, et al. 2'-Deoxyadenosine causes apoptotic cell death in a human colon carcinoma cell line. J Biochem Mol Toxicol. 2003;17 (6) :329-37.|[3]Cass CE, et al. Effects of 2'-deoxyadenosine, 9-beta-D-arabinofuranosyladenine, and related compounds on S-adenosyl-L-homocysteine hydrolase activity in synchronous and asynchronous cultured cells. Cancer Res. 1982 Dec;42 (12) :4991-8.|[4]Iizuka H, et al. Effects of adenosine and 2'-deoxyadenosine on epidermal keratinocyte proliferation: its relation to cyclic AMP formation. J Invest Dermatol. 1984 Jun;82 (6) :608-12.|[5]Bemi V, et al. Deoxyadenosine metabolism in a human colon-carcinoma cell line (LoVo) in relation to its cytotoxic effect in combination with deoxycoformycin. Int J Cancer. 1998 Mar 2;75 (5) :713-20.|[6]Wakade AR, et al. 2'-deoxyadenosine induces apoptosis in rat chromaffin cells. J Neurochem. 1996 Dec;67 (6) :2273-81.|[7]Gao X, et al. Activation of apoptosis in early mouse embryos by 2'-deoxyadenosine exposure. Teratology. 1994 Jan;49 (1) :1-12. |[8]Kuttesch JF Jr, et al. Renal handling of 2'-deoxyadenosine and adenosine in humans and mice. Cancer Chemother Pharmacol. 1982;8 (2) :221-9.

Room Temperature

4°C (Powder, protect from light)

Natural Products

No Development Reported