RO 2468

• Description:

  RO 2468 is a potent, orally active and selective p53-MDM2 inhibitor. RO 2468 has anti-proliferative active. RO 2468 suppresses c growth in SJSA1 osteosarcoma models without obvious toxicity[1].

• UNSPSC:

  12352005

• Target:

  MDM-2/p53

• Type:

  Reference compound

• Related Pathways:

  Apoptosis

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/ro-2468.html

• Solubility:

  10 mM in DMSO

• Smiles:

  COC1=C(NC([C@H]2[C@H](C3=C(F)C(Cl)=CC=C3)[C@@]4(C5=CN=C(Cl)C=C5NC4=O)[C@H](CC(C)(C)C)N2)=O)C=CC(C(N)=O)=C1

• Molecular Formula:

  C30H30Cl2FN5O4

• Molecular Weight:

  614.49

• References & Citations:

  [1]Zhang Z, et, al. Discovery of Potent and Orally Active p53-MDM2 Inhibitors RO5353 and RO2468 for Potential Clinical Development. ACS Med Chem Lett. 2013 Dec 29;5 (2) :124-7.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [1360821-21-1]