RO 2468

CAT: 0804-HY-12579Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-12579Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
RO 2468 is a potent, orally active and selective p53-MDM2 inhibitor. RO 2468 has anti-proliferative active. RO 2468 suppresses c growth in SJSA1 osteosarcoma models without obvious toxicity[1].
CAS Number
[1360821-21-1]
UNSPSC
12352005
Target
MDM-2/p53
Type
Reference compound
Related Pathways
Apoptosis
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ro-2468.html
Solubility
10 mM in DMSO
Smiles
COC1=C(NC([C@H]2[C@H](C3=C(F)C(Cl)=CC=C3)[C@@]4(C5=CN=C(Cl)C=C5NC4=O)[C@H](CC(C)(C)C)N2)=O)C=CC(C(N)=O)=C1
Molecular Formula
C30H30Cl2FN5O4
Molecular Weight
614.49
References & Citations
[1]Zhang Z, et, al. Discovery of Potent and Orally Active p53-MDM2 Inhibitors RO5353 and RO2468 for Potential Clinical Development. ACS Med Chem Lett. 2013 Dec 29;5 (2) :124-7.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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