ENMD-1068

• Description:

  ENMD-1068 is a selective protease-activated receptor 2 (PAR2) antagonist. ENMD-1068 reduces hepatic stellate cell activation and collagen expression by inhibiting TGF-β1/Smad signaling. ENMD-1068 also inhibits the proliferation of endometrial cells and induces apoptosis of epithelial cells in the lesion. ENMD-1068 can be used in the study of endometriosis and liver fibrosis[1][2].

• UNSPSC:

  12352005

• Hazard Statement:

  H302

• Target:

  Apoptosis; Protease Activated Receptor (PAR)

• Type:

  Reference compound

• Related Pathways:

  Apoptosis; GPCR/G Protein

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Inflammation/Immunology

• Assay Protocol:

  https://www.medchemexpress.com/enmd-1068.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C(N1CCN(C(CC(C)C)=O)CC1)CCCCCN

• Molecular Formula:

  C15H29N3O2

• Molecular Weight:

  283.41

• Precautions:

  P264-P270-P330-P501

• References & Citations:

  [1]Sun Q, et al. ENMD-1068 inhibits liver fibrosis through attenuation of TGF-β1/Smad2/3 signaling in mice. Sci Rep. 2017 Jul 14;7 (1) :5498. doi: 10.1038/s41598-017-05190-7. Erratum in: Sci Rep. 2019 Dec 10;9 (1) :19125.|[2]Wang Y, et al. ENMD-1068, a protease-activated receptor 2 antagonist, inhibits the development of endometriosis in a mouse model. Am J Obstet Gynecol. 2014 Jun;210 (6) :531.e1-8.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  PAR2

• CAS Number:

  [789488-77-3]