ENMD-1068

ENMD-1068

• CAS Number: 789488-77-3
• UNSPSC Description: ENMD-1068 is a selective protease-activated receptor 2 (PAR2) antagonist. ENMD-1068 reduces hepatic stellate cell activation and collagen expression by inhibiting TGF-β1/Smad signaling. ENMD-1068 also inhibits the proliferation of endometrial cells and induces apoptosis of epithelial cells in the lesion. ENMD-1068 can be used in the study of endometriosis and liver fibrosis[1][2].
• Target Antigen: Apoptosis; Protease Activated Receptor (PAR)
• Type: Reference compound
• Related Pathways: Apoptosis;GPCR/G Protein
• Applications: COVID-19-immunoregulation
• Field of Research: Inflammation/Immunology
• Assay Protocol: https://www.medchemexpress.com/enmd-1068.html
• Solubility: 10 mM in DMSO
• Smiles: O=C(N1CCN(C(CC(C)C)=O)CC1)CCCCCN
• Molecular Weight: 283.41
• References & Citations: [1]Sun Q, et al. ENMD-1068 inhibits liver fibrosis through attenuation of TGF-β1/Smad2/3 signaling in mice. Sci Rep. 2017 Jul 14;7(1):5498. doi: 10.1038/s41598-017-05190-7. Erratum in: Sci Rep. 2019 Dec 10;9(1):19125.|[2]Wang Y, et al. ENMD-1068, a protease-activated receptor 2 antagonist, inhibits the development of endometriosis in a mouse model. Am J Obstet Gynecol. 2014 Jun;210(6):531.e1-8.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported