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ENMD-1068

CAT: 0804-HY-124748Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-124748Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
ENMD-1068 is a selective protease-activated receptor 2 (PAR2) antagonist. ENMD-1068 reduces hepatic stellate cell activation and collagen expression by inhibiting TGF-β1/Smad signaling. ENMD-1068 also inhibits the proliferation of endometrial cells and induces apoptosis of epithelial cells in the lesion. ENMD-1068 can be used in the study of endometriosis and liver fibrosis[1][2].
CAS Number
789488-77-3
UNSPSC
12352005
Hazard Statement
H302
Target
Apoptosis; Protease Activated Receptor (PAR)
Type
Reference compound
Related Pathways
Apoptosis; GPCR/G Protein
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/enmd-1068.html
Solubility
10 mM in DMSO
Smiles
O=C(N1CCN(C(CC(C)C)=O)CC1)CCCCCN
Molecular Formula
C15H29N3O2
Molecular Weight
283.41
Precautions
P264-P270-P330-P501
References & Citations
[1]Sun Q, et al. ENMD-1068 inhibits liver fibrosis through attenuation of TGF-β1/Smad2/3 signaling in mice. Sci Rep. 2017 Jul 14;7 (1) :5498. doi: 10.1038/s41598-017-05190-7. Erratum in: Sci Rep. 2019 Dec 10;9 (1) :19125.|[2]Wang Y, et al. ENMD-1068, a protease-activated receptor 2 antagonist, inhibits the development of endometriosis in a mouse model. Am J Obstet Gynecol. 2014 Jun;210 (6) :531.e1-8.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PAR2

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