KMG-1068

• Description:

  KMG-1068 (Compound 4a), a molecular glue, is a GSPT1/2 degrader. KMG-1068 effectively induces the CRBN-dependent degradation of GSPT1/2 by binding to the IMiD binding site on CRBN, facilitating the formation of a ternary complex with GSPT1/2. KMG-1068 is promising for research of cancers[1].

• UNSPSC:

  12352211

• Target:

  Molecular Glues

• Related Pathways:

  PROTAC

• Field of Research:

  Cancer

• Smiles:

  O=C1C(C)=C(C)N=CN1CC(NC2=NC(C(OC)=O)=C(CCC3=CC=CC=C3)S2)=O

• Molecular Formula:

  C21H22N4O4S

• Molecular Weight:

  426.49

• References & Citations:

  [1]Park S, et al. Discovery of a novel molecular glue degrader targeting GSPT1/2 with a non-IMiD-based CRBN binder. Eur J Med Chem. 2025 Apr 15;291:117642.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported