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ENMD-1198

CAT: 0804-HY-16196-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-16196-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
ENMD-1198 (IRC-110160), an orally active microtubule destabilizing agent, is a 2-methoxyestradiol analogue with antiproliferative and antiangiogenic activity. ENMD-1198 is suitable for inhibiting HIF-1alpha and STAT3 in human HCC cells and leads to reduced tumor growth and vascularization.
CAS Number
864668-87-1
Product Name Alternative
IRC-110160
UNSPSC
12352005
Target
HIF/HIF Prolyl-Hydroxylase; Microtubule/Tubulin; STAT
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Cytoskeleton; JAK/STAT Signaling; Metabolic Enzyme/Protease; Stem Cell/Wnt
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ENMD-119.html
Purity
98.87
Solubility
DMSO : 100 mg/mL (ultrasonic; warming)
Smiles
C[C@@]12C=CC[C@@]1([H])[C@]3([H])CCC4=C(C=C(OC)C(C(N)=O)=C4)[C@@]3([H])CC2
Molecular Formula
C20H25NO2
Molecular Weight
311.42
References & Citations
[1]Pasquier E, et al. ENMD-1198, a new analogue of 2-methoxyestradiol, displays both antiangiogenic and vascular-disrupting properties. Mol Cancer Ther. 2010 May;9 (5) :1408-18.|[2]Snoeks TJ, et al. 2-methoxyestradiol analogue ENMD-1198 reduces breast cancer-induced osteolysis and tumor burden both in vitro and in vivo. Mol Cancer Ther. 2011 May;10 (5) :874-82.|[3]Moser C, et al. ENMD-1198, a novel tubulin-binding agent reduces HIF-1alpha and STAT3 activity in human hepatocellular carcinoma (HCC) cells, and inhibits growth and vascularization in vivo. BMC Cancer. 2008 Jul 23;8:206.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 1
Isoform
STAT3

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