1'-Hydroxy bufuralol-d9

• Description :

  1'-Hydroxy bufuralol-d9 is a deuterium labeled 1'-Hydroxy bufuralol (HY-122277) . 1'-Hydroxy bufuralol, the main metabolite of bufuralol, can reflect CYP2D activity[1][2].

• CAS Number :

  [1185069-74-2]

• UNSPSC :

  12352005

• Target :

  Cytochrome P450; Isotope-Labeled Compounds

• Type :

  Isotope-Labeled Compounds

• Related Pathways :

  Metabolic Enzyme/Protease; Others

• Applications :

  Metabolism-protein/nucleotide metabolism

• Field of Research :

  Metabolic Disease

• Purity :

  99.9

• Solubility :

  10 mM in DMSO

• Smiles :

  CC(C1=C2C(C=C(O2)C(O)CNC(C([2H])([2H])[2H])(C([2H])([2H])[2H])C([2H])([2H])[2H])=CC=C1)O

• Molecular Formula :

  C16H14D9NO3

• Molecular Weight :

  286.41

• References & Citations :

  [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53 (2) :211-246.|[2]Evangelos P Daskalopoulos, et al. D₂-dopaminergic receptor-linked pathways: critical regulators of CYP3A, CYP2C, and CYP2D. Mol Pharmacol. 2012 Oct;82 (4) :668-78.|[3]H Yamazaki, et al. Bufuralol hydroxylation by cytochrome P450 2D6 and 1A2 enzymes in human liver microsomes. Mol Pharmacol. 1994 Sep;46 (3) :568-77.

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  -20°C, 3 years (Powder)

• Scientific Category :

  Isotope-Labeled Compounds

• Clinical Information :

  No Development Reported