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1'-Hydroxy bufuralol-d9

CAT: 0804-HY-122277SSize: 500 µgDry Ice: NoHazardous: No
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CAT#:0804-HY-122277SSize:500 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
1'-Hydroxy bufuralol-d9 is a deuterium labeled 1'-Hydroxy bufuralol. 1'-Hydroxy bufuralol, the main metabolite of bufuralol, can reflect CYP2D activity[1][2].
CAS Number
1185069-74-2
UNSPSC
12352005
Target
Cytochrome P450; Isotope-Labeled Compounds
Type
Isotope-Labeled Compounds
Related Pathways
Metabolic Enzyme/Protease; Others
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease
Purity
99.9
Solubility
10 mM in DMSO
Smiles
CC(C1=C2C(C=C(O2)C(O)CNC(C([2H])([2H])[2H])(C([2H])([2H])[2H])C([2H])([2H])[2H])=CC=C1)O
Molecular Formula
C16H14D9NO3
Molecular Weight
286.41
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53 (2) :211-246.|[2]Evangelos P Daskalopoulos, et al. D₂-dopaminergic receptor-linked pathways: critical regulators of CYP3A, CYP2C, and CYP2D. Mol Pharmacol. 2012 Oct;82 (4) :668-78.|[3]H Yamazaki, et al. Bufuralol hydroxylation by cytochrome P450 2D6 and 1A2 enzymes in human liver microsomes. Mol Pharmacol. 1994 Sep;46 (3) :568-77.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported

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TRC-H830482-0.5MG1?-Hydroxy Bufuralol-d9 (Mixture of Diastereomers)
TRC-H830482-5MG1’-Hydroxy Bufuralol-d9 (Mixture of Diastereomers)
GTR192385491'-Hydroxy bufuralol
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