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Bufuralol (hydrochloride) (Standard)

CAT: 0804-HY-105124ARSize: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-105124ARSize:1 Each
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Description
Bufuralol (hydrochloride) (Standard) is the analytical standard of Bufuralol (hydrochloride) . This product is intended for research and analytical applications. Bufuralol (Ro 3-4787) hydrochloride is a potent non-selective, orally active β-adrenoreceptor antagonist with partial agonist activity. Bufuralol hydrochloride is a CYP2D6 probe substrate[1][2].
CAS Number
60398-91-6
Product Name Alternative
Ro 3-4787 (hydrochloride) (Standard)
UNSPSC
12352005
Target
Adrenergic Receptor; Reference Standards
Related Pathways
GPCR/G Protein; Neuronal Signaling; Others
Field of Research
Endocrinology; Cardiovascular Disease
Smiles
OC(CNC(C)(C)C)C1=CC2=CC=CC(CC)=C2O1.[H]Cl
Molecular Formula
C16H24ClNO2
Molecular Weight
297.82
References & Citations
[1]T H Pringle, et al. Pharmacodynamic and pharmacokinetic studies on bufuralol in man. Br J Clin Pharmacol. 1986 Nov;22 (5) :527-34.|[2]Jie Cai, et al. Effects of 22 Novel CYP2D6 Variants Found in the Chinese Population on the Bufuralol and Dextromethorphan Metabolisms In Vitro. Basic Clin Pharmacol Toxicol. 2016 Mar;118 (3) :190-9.|[3]Sarah M Glass, et al. CYP2D6 Allelic Variants *34, *17-2, *17-3, and *53 and a Thr309Ala Mutant Display Altered Kinetics and NADPH Coupling in Metabolism of Bufuralol and Dextromethorphan and Altered Susceptibility to Inactivation by SCH 66712. Drug Metab Dispos. 2018 Aug;46 (8) :1106-1117.|[4]T Prueksaritanont, et al. (+) -bufuralol 1'-hydroxylation activity in human and rhesus monkey intestine and liver. Biochem Pharmacol. 1995 Oct 26;50 (9) :1521-5.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards

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