Bufuralol (hydrochloride)

• Description :

  Bufuralol (Ro 3-4787) hydrochloride is a potent non-selective, orally active β-adrenoreceptor antagonist with partial agonist activity. Bufuralol hydrochloride is a CYP2D6 probe substrate[1][2].

• Product Name Alternative :

  Ro 3-4787 (hydrochloride)

• UNSPSC :

  12352005

• Hazard Statement :

  H302

• Target :

  Adrenergic Receptor

• Type :

  Reference compound

• Related Pathways :

  GPCR/G Protein; Neuronal Signaling

• Applications :

  Metabolism-protein/nucleotide metabolism

• Field of Research :

  Endocrinology; Cardiovascular Disease

• Assay Protocol :

  https://www.medchemexpress.com/bufuralol-hydrochloride.html

• Concentration :

  10mM

• Purity :

  99.0

• Solubility :

  DMSO : 100 mg/mL (ultrasonic)

• Smiles :

  OC(CNC(C)(C)C)C1=CC2=CC=CC(CC)=C2O1.[H]Cl

• Molecular Formula :

  C16H24ClNO2

• Molecular Weight :

  297.82

• Precautions :

  H302

• References & Citations :

  [1]T H Pringle, et al. Pharmacodynamic and pharmacokinetic studies on bufuralol in man. Br J Clin Pharmacol. 1986 Nov;22 (5) :527-34.|[2]Jie Cai, et al. Effects of 22 Novel CYP2D6 Variants Found in the Chinese Population on the Bufuralol and Dextromethorphan Metabolisms In Vitro. Basic Clin Pharmacol Toxicol. 2016 Mar;118 (3) :190-9.|[3]Sarah M Glass, et al. CYP2D6 Allelic Variants *34, *17-2, *17-3, and *53 and a Thr309Ala Mutant Display Altered Kinetics and NADPH Coupling in Metabolism of Bufuralol and Dextromethorphan and Altered Susceptibility to Inactivation by SCH 66712. Drug Metab Dispos. 2018 Aug;46 (8) :1106-1117.|[4]T Prueksaritanont, et al. (+) -bufuralol 1'-hydroxylation activity in human and rhesus monkey intestine and liver. Biochem Pharmacol. 1995 Oct 26;50 (9) :1521-5.

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  -20°C (Powder, sealed storage, away from moisture)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  β adrenergic receptor

• CAS Number :

  [60398-91-6]