1'-Hydroxy bufuralol

• Description :

  1'-Hydroxy bufuralol, the main metabolite of bufuralol, can reflect CYP2D activity[1].

• UNSPSC :

  12352005

• Hazard Statement :

  H302

• Target :

  Cytochrome P450

• Type :

  Reference compound

• Related Pathways :

  Metabolic Enzyme/Protease

• Applications :

  Metabolism-protein/nucleotide metabolism

• Field of Research :

  Metabolic Disease

• Assay Protocol :

  https://www.medchemexpress.com/1-hydroxy-bufuralol.html

• Purity :

  99.00

• Solubility :

  10 mM in DMSO

• Smiles :

  CC(C1=C2OC(C(CNC(C)(C)C)O)=CC2=CC=C1)O

• Molecular Formula :

  C16H23NO3

• Molecular Weight :

  277.36

• Precautions :

  H302

• References & Citations :

  [1]Evangelos P Daskalopoulos, et al. D₂-dopaminergic receptor-linked pathways: critical regulators of CYP3A, CYP2C, and CYP2D. Mol Pharmacol. 2012 Oct;82 (4) :668-78.|[2]H Yamazaki, et al. Bufuralol hydroxylation by cytochrome P450 2D6 and 1A2 enzymes in human liver microsomes. Mol Pharmacol. 1994 Sep;46 (3) :568-77.

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  -20°C (Powder, sealed storage, away from moisture)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  CYP2

• CAS Number :

  [57704-16-2]