ONO-8711

• Description :

  ONO-8711 is a potent and selective competitive antagonist of EP1 receptor (Ki = 0.6 and 1.7 nM for human and mouse EP1 respectively) . ONO-8711 effectively reduces tumor incidence and multiplicity in mouse models of colon, breast, and oral cancer[1].

• UNSPSC :

  12352005

• Target :

  Prostaglandin Receptor

• Type :

  Reference compound

• Related Pathways :

  GPCR/G Protein

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/ono-8711.html

• Solubility :

  10 mM in DMSO

• Smiles :

  O=C(O)CCC/C=C\[C@H]1C(CC2)CCC2[C@@H]1CNS(=O)(C3=CC=C(Cl)C=C3C)=O

• Molecular Formula :

  C22H30ClNO4S

• Molecular Weight :

  440.00

• References & Citations :

  [1]Watanabe K, et al. Role of the prostaglandin E receptor subtype EP1 in colon carcinogenesis. Cancer Res. 1999 Oct 15;59 (20) :5093-6. |[2]Norel X, et al. Vasoconstriction induced by activation of EP1 and EP3 receptors in human lung: effects of ONO-AE-248, ONO-DI-004, ONO-8711 or ONO-8713. Prostaglandins Other Lipid Mediat. 2004 Oct;74 (1-4) :101-12.|[3]Kawamori T, et al. Chemopreventive effects of ONO-8711, a selective prostaglandin E receptor EP (1) antagonist, on breast cancer development. Carcinogenesis. 2001 Dec;22 (12) :2001-4.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  EP

• CAS Number :

  [216158-34-8]