PF-00217830

• Description :

  F-00217830 is an agonist ofDopamine D2 receptor. PF-00217830 inhibits of spontaneous locomotor activity and 2,5-dimethoxy-4-iodoamphetamine-induced head twitches in rats[1].

• UNSPSC :

  12352005

• Target :

  Dopamine Receptor

• Type :

  Reference compound

• Related Pathways :

  GPCR/G Protein; Neuronal Signaling

• Applications :

  Neuroscience-Neuromodulation

• Field of Research :

  Neurological Disease

• Assay Protocol :

  https://www.medchemexpress.com/pf-00217830.html

• Solubility :

  10 mM in DMSO

• Smiles :

  O=C1N=C2NC(OCCCCN3CCN(CC3)C4=C5C=CC=CC5=CC=C4)=CC=C2CC1

• Molecular Formula :

  C26H30N4O2

• Molecular Weight :

  430.54

• References & Citations :

  [1]Johnson DS, et al. Discovery of PF-00217830: aryl piperazine napthyridinones as D2 partial agonists for schizophrenia and bipolar disorder. Bioorg Med Chem Lett. 2011;21 (9) :2621-2625.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  Phase 2

• CAS Number :

  [846032-02-8]