AGI-5198

CAT: 0804-HY-18082-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-18082-01Size:5 mg
Selected
PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
Description
AGI-5198 (IDH-C35) is a potent and selective mutant IDH1R132H inhibitor with an IC50 of 0.07 μM.
CAS Number
[1355326-35-0]
Product Name Alternative
IDH-C35
UNSPSC
12352005
Hazard Statement
H301
Target
Isocitrate Dehydrogenase (IDH)
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/AGI-5198.html
Purity
99.93
Solubility
DMF : ≥ 50 mg/mL|DMSO : 20.83 mg/mL (ultrasonic)
Smiles
FC1=CC=CC(N(C(C2=CC=CC=C2C)C(NC3CCCCC3)=O)C(CN4C=CN=C4C)=O)=C1
Molecular Formula
C27H31FN4O2
Molecular Weight
462.56
Precautions
H301
References & Citations
[1]Rohle D, et al. An inhibitor of mutant IDH1 delays growth and promotes differentiation of glioma cells. Science. 2013 May 3;340 (6132) :626-30.|[2]Molenaar RJ, et al. Radioprotection of IDH1-Mutated Cancer Cells by the IDH1-Mutant Inhibitor AGI-5198. Cancer Res. 2015 Nov 15;75 (22) :4790-802.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
IDH1

Related Products

CatalogName
HY-156996AGI-134
HY-112129-01AGI-25696
HY-121736-01AGI-12026
HY-145778-01AGI-41998
HY-145777-01AGI-43192
HY-112130-01AGI-24512
HY-120181-01AGI-14100
HY-15734-01AGI-6780
HY-15293JTV-519
HY-116078-01CKD-519

Alternative Products

CatalogName
GW1673-25mgAGI-5198
7087/25AGI 5198
MBS577136AGI-5198 (IDH-C35)
A12902-200AGI-5198 (IDH-C35) 200mg
A12902-5AGI-5198 (IDH-C35) 5mg
A12902-10AGI-5198 (IDH-C35) 10mg
A12902-25AGI-5198 (IDH-C35) 25mg
A12902-100AGI-5198 (IDH-C35) 100mg
A12902-50AGI-5198 (IDH-C35) 50mg
A12902-500AGI-5198 (IDH-C35) 500mg

Popular Products