AGI-5198

• Description:

  AGI-5198 (IDH-C35) is a potent and selective mutant IDH1R132H inhibitor with an IC50 of 0.07 μM.

• Product Name Alternative:

  IDH-C35

• UNSPSC:

  12352005

• Hazard Statement:

  H301

• Target:

  Isocitrate Dehydrogenase (IDH)

• Type:

  Reference compound

• Related Pathways:

  Metabolic Enzyme/Protease

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/AGI-5198.html

• Purity:

  99.93

• Solubility:

  DMF : ≥ 50 mg/mL|DMSO : 20.83 mg/mL (ultrasonic)

• Smiles:

  FC1=CC=CC(N(C(C2=CC=CC=C2C)C(NC3CCCCC3)=O)C(CN4C=CN=C4C)=O)=C1

• Molecular Formula:

  C27H31FN4O2

• Molecular Weight:

  462.56

• Precautions:

  H301

• References & Citations:

  [1]Rohle D, et al. An inhibitor of mutant IDH1 delays growth and promotes differentiation of glioma cells. Science. 2013 May 3;340 (6132) :626-30.|[2]Molenaar RJ, et al. Radioprotection of IDH1-Mutated Cancer Cells by the IDH1-Mutant Inhibitor AGI-5198. Cancer Res. 2015 Nov 15;75 (22) :4790-802.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  IDH1

• CAS Number:

  [1355326-35-0]