AGI-026

• Target :

  Isocitrate Dehydrogenase (IDH)

• Related Pathways :

  Metabolism

• Purity :

  0.9986

• Bioactivity :

  AGI-026 (AGI-12026) is a novel and potent dual inhibitor of the mutant isocitrate dehydrogenase mIDH1/2 with the advantages of oral administration and penetration of the blood-brain barrier, with a drug concentration to plasma concentration ratio (brain/plasma ratio) of 1.5 in brain tissue, and the ability to reduce the accumulation of the carcinogenic metabolite d-2-hydroxyglutarate (2-HG), which is used in the study of mIDH gliomas.

• Smiles :

  FC(F)(F)C1=NC(=CC=C1)C=2N=C(N=C(N2)NC(C)C)NC=3C=CN=C(C3)C(F)(F)F

• Molecular Formula :

  C18H15F6N7

• Molecular Weight :

  443.35

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C

• CAS Number :

  1446501-77-4