Ac-YVAD-pNA

Ac-YVAD-pNA

• CAS Number: 149231-66-3
• UNSPSC Description: Ac-YVAD-pNA is a specific Caspase-1 substrate. Ac-YVAD-pNA can be used to detect Caspase-1 activity. Caspase-1 is a key mediator of inflammatory processes[1][2].
• Target Antigen: Caspase
• Type: Peptides
• Related Pathways: Apoptosis
• Applications: COVID-19-immunoregulation
• Field of Research: Inflammation/Immunology
• Assay Protocol: https://www.medchemexpress.com/ac-yvad-pna.html
• Purity: 99.93
• Solubility: DMSO : ≥ 250 mg/mL
• Smiles: O=C(NC1=CC=C([N+]([O-])=O)C=C1)[C@H](CC(O)=O)NC([C@H](C)NC([C@H](C(C)C)NC([C@@H](NC(C)=O)CC2=CC=C(O)C=C2)=O)=O)=O
• Molecular Weight: 628.63
• References & Citations: [1]Pereira NA, et al. Some commonly used caspase substrates and inhibitors lack the specificity required to monitor individual caspase activity. Biochem Biophys Res Commun. 2008 Dec 19;377(3):873-7. |[2]Xin W, Wang Q, et al. A new mechanism of inhibition of IL-1β secretion by celastrol through the NLRP3 inflammasome pathway. Eur J Pharmacol. 2017 Nov 5;814:240-247.
• Shipping Conditions: Blue Ice
• Storage Conditions: -80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture and light)
• Clinical Information: No Development Reported