Ac-YVAD-AFC

Ac-YVAD-AFC

• CAS Number: 219137-85-6
• UNSPSC Description: Ac-YVAD-AFC is the the fluorometric peptide substrate of caspase-1, with λ excitation of 400 nm and λ emission of 505 nm[1][2].
• Target Antigen: Fluorescent Dye
• Type: Dye Reagents
• Related Pathways: Others
• Field of Research: Others
• Assay Protocol: https://www.medchemexpress.com/ac-yvad-afc.html
• Purity: 99.56
• Solubility: DMSO : 100 mg/mL (ultrasonic)
• Smiles: FC(F)(C(C(C(O1)=C2)=CC=C2NC([C@H](CC(O)=O)NC([C@H](C)NC([C@H](C(C)C)NC([C@@H](NC(C)=O)CC(C=C3)=CC=C3O)=O)=O)=O)=O)=CC1=O)F
• Molecular Weight: 719.66
• References & Citations: [1]Furuoka M, et al. TNF-α Induces Caspase-1 Activation Independently of Simultaneously Induced NLRP3 in 3T3-L1 Cells. J Cell Physiol. 2016 Dec;231(12):2761-7.|[2]Guo RF, et al. Protective effects of anti-C5a in sepsis-induced thymocyte apoptosis. J Clin Invest. 2000 Nov;106(10):1271-80.
• Shipping Conditions: Blue Ice
• Storage Conditions: -80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture and light, under nitrogen)
• Clinical Information: No Development Reported