Ro 363

• Description :

  Ro 363, an effective inotropic stimulant, is a potent and highly selective β1-adrenoceptor agonist. RO 363 is a cardiovascular modulator that reduces diastolic blood pressure and pronounces increases in myocardial contractility[1][2][3].

• UNSPSC :

  12352005

• Target :

  Adrenergic Receptor

• Type :

  Reference compound

• Related Pathways :

  GPCR/G Protein; Neuronal Signaling

• Applications :

  Neuroscience-Neuromodulation

• Field of Research :

  Cardiovascular Disease

• Assay Protocol :

  https://www.medchemexpress.com/ro-363.html

• Solubility :

  10 mM in DMSO

• Smiles :

  OC1=CC=C(C=C1O)OCC(CNCCC2=CC=C(C(OC)=C2)OC)O

• Molecular Formula :

  C19H25NO6

• Molecular Weight :

  363.40

• References & Citations :

  [1]Maccarrone C, et al. Comparison of the Arrhythmogenic Actions of (-) -Isoprenaline, Dobutamine and the selective beta 1-adrenoceptor agonist, (+/-) - (1-[3',4'-dihydroxyphenoxy] -2-hydroxy-[3",4"-dimethoxy phenethylamino]-propane) -oxalate (Ro 363) . Arzneimittelforschung. 1985;35 (3) :592-8.|[2]Iakovidis D, et al. In vitro activity of RO363, a beta1-adrenoceptor selective agonist. Br J Pharmacol. 1980 Apr;68 (4) :677-85.|[3]Einstein R, et al. Comparison of the cardiac effects of beta-adrenoreceptor agonists in anaesthetised and conscious dogs. J Auton Pharmacol. 1986 Mar;6 (1) :9-14.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  β adrenergic receptor

• CAS Number :

  [74513-77-2]