OP-3633

• Description :

  OP-3633 is a potent and selective steroidal glucocorticoid receptor (GR) antagonist with an IC50 of 29 nM, with inhibition of GR transcriptional activity. OP-3633 exhibits low progesterone receptor (PR) agonism and androgen receptor (AR) antagonism[1].

• UNSPSC :

  12352005

• Target :

  Glucocorticoid Receptor

• Type :

  Reference compound

• Related Pathways :

  Immunology/Inflammation; Vitamin D Related/Nuclear Receptor

• Applications :

  Metabolism-sugar/lipid metabolism

• Field of Research :

  Inflammation/Immunology; Endocrinology

• Assay Protocol :

  https://www.medchemexpress.com/op-3633.html

• Solubility :

  10 mM in DMSO

• Smiles :

  O=C1CC[C@]2(C)[C@@]3([H])[C@@H](C4=CC=C(N(C)C)C=C4)C[C@]5(C)[C@@](C#CC)(O)CC[C@@]5([H])[C@]3([H])CCC2=C1

• Molecular Formula :

  C30H39NO2

• Molecular Weight :

  445.64

• References & Citations :

  [1]Du X, et al. Discovery of a Potent Steroidal Glucocorticoid Receptor Antagonist with Enhanced Selectivity against the Progesterone and Androgen Receptors (OP-3633) . J Med Chem. 2019 Jul 25;62 (14) :6751-6764.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [2102494-14-2]