OP-3633

CAT: 0804-HY-125839Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-125839Size:1 Each
Selected
PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
Description
OP-3633 is a potent and selective steroidal glucocorticoid receptor (GR) antagonist with an IC50 of 29 nM, with inhibition of GR transcriptional activity. OP-3633 exhibits low progesterone receptor (PR) agonism and androgen receptor (AR) antagonism[1].
CAS Number
[2102494-14-2]
UNSPSC
12352005
Target
Glucocorticoid Receptor
Type
Reference compound
Related Pathways
Immunology/Inflammation; Vitamin D Related/Nuclear Receptor
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Inflammation/Immunology; Endocrinology
Assay Protocol
https://www.medchemexpress.com/op-3633.html
Solubility
10 mM in DMSO
Smiles
O=C1CC[C@]2(C)[C@@]3([H])[C@@H](C4=CC=C(N(C)C)C=C4)C[C@]5(C)[C@@](C#CC)(O)CC[C@@]5([H])[C@]3([H])CCC2=C1
Molecular Formula
C30H39NO2
Molecular Weight
445.64
References & Citations
[1]Du X, et al. Discovery of a Potent Steroidal Glucocorticoid Receptor Antagonist with Enhanced Selectivity against the Progesterone and Androgen Receptors (OP-3633) . J Med Chem. 2019 Jul 25;62 (14) :6751-6764.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Related Products

CatalogName
HY-P10345OP-145
HY-136978-01OP-5244
HY-125263-01OP-1074
HY-106110OP-2507
HY-136978A-01OP-5244 (sodium)
HY-125263B-01(R) -OP-1074
HY-118695IRL-3630
HY-180376TAC 363
HY-155285-01YS-363
HY-123268Ro 363

Alternative Products

CatalogName
MBS3842932-01OP-3633
A18468-10OP-3633 10mg
A18468-5OP-3633 5mg
A18468-50OP-3633 50mg
A18468-25OP-3633 25mg
3219843633-0054 Card Printer Accessories
3219833633-0053 Card Printer Accessories
MBS5777947OP-2507
O012-5MGOP-145
sc-477439AOP-1118

Popular Products