RegisterLogin

AVE-0118

CAT: 0804-HY-118387Size: 1 mgDry Ice: NoHazardous: No
CAT#:0804-HY-118387Size:1 mg
Selected
PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
Description
AVE-0118 is a nonselective Kv1.5 blocker with an IC50 of 1.1 μM. AVE-0118 is a multichannel inhibitor with weak, micromolar activity against Kv1.5 and other ion channels. It is inactive against IKs, IKATP, and L-type Ca+ channels[1].
CAS Number
[498577-53-0]
UNSPSC
12352005
Target
Potassium Channel
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/ave-0118.html
Solubility
10 mM in DMSO
Smiles
O=C(NCCC1=CC=CN=C1)C2=CC=CC=C2C3=CC=CC=C3CNC(CC4=CC=C(C=C4)OC)=O
Molecular Formula
C30H29N3O3
Molecular Weight
479.57
References & Citations
[1]Bilodeau MT, et al. Kv1.5 blockers for the treatment of atrial fibrillation: approaches to optimization of potency and selectivity and translation to in vivo pharmacology. Curr Top Med Chem. 2009;9 (5) :436-51.|[2]Kun A, et al. Neurogenic contraction induced by the antiarrhythmic compound, AVE 0118, in rat small mesenteric arteries. Basic Clin Pharmacol Toxicol. 2014 Oct;115 (4) :315-20.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 1

Related Products

CatalogName
HY-176535KB-0118
HY-122005-01AVE-9488
HY-117867-01AVE-8063
HY-U00014AVE-8134
HY-15778-01AVE 0991
HY-19841AVE-5997
HY-117867A-01AVE-8063 (hydrochloride)
HY-15778A-01AVE 0991 (sodium salt)
HY-167886GA 0113
HY-179094PSP-0119

Alternative Products

CatalogName
MBS3604668-01AVE-0118
MBS5796617Compound 0118-0250
IL-0118-HP-BULKIoLiLyt 0118
T211196-01KB-0118
MBS5779855AVE-9488
sc-221277AAVE-1625
B1007-25AVE 0991
OR1036067-01AVE-8063
MBS5754550AVE-3085
T131221-01Compound N060-0118

Popular Products