AVE 0991

• Description:

  AVE 0991 is a nonpeptide and orally active angiotensin- (1-7) receptor agonist with an IC50 of 21 nM[1].

• UNSPSC:

  12352005

• Hazard Statement:

  H302, H315, H319, H335

• Target:

  Angiotensin Receptor

• Type:

  Reference compound

• Related Pathways:

  GPCR/G Protein

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Cardiovascular Disease; Endocrinology

• Assay Protocol:

  https://www.medchemexpress.com/AVE-0991.html

• Purity:

  99.91

• Solubility:

  DMSO : 41.67 mg/mL (ultrasonic)

• Smiles:

  O=S(C1=C(C2=CC=C(CN3C(C=O)=C(OC)N=C3C4=CC=CC=C4)C=C2)C=C(CC(C)C)S1)(NC(NCC)=O)=O

• Molecular Formula:

  C29H32N4O5S2

• Molecular Weight:

  580.72

• Precautions:

  H302, H315, H319, H335

• References & Citations:

  [1]Wiemer G, et al. AVE 0991, a nonpeptide mimic of the effects of angiotensin- (1-7) on the endothelium. Hypertension. 2002 Dec;40 (6) :847-52.|[2]Pinheiro SV, et al. Nonpeptide AVE 0991 is an angiotensin- (1-7) receptor Mas agonist in the mouse kidney. Hypertension. 2004 Oct;44 (4) :490-6.|[3]Ferreira AJ, et al. The nonpeptide angiotensin- (1-7) receptor Mas agonist AVE-0991 attenuates heart failure induced by myocardial infarction. Am J Physiol Heart Circ Physiol. 2007 Feb;292 (2) :H1113-9.|[4]Mo J, et al. AVE 0991 attenuates oxidative stress and neuronal apoptosis via Mas/PKA/CREB/UCP-2 pathway after subarachnoid hemorrhage in rats. Redox Biol. 2018 Sep 28;20:75-86.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Citation 01:

  Aging (Albany NY) . 2018 Apr 17;10 (4) :645-657. |Biochem Pharmacol. 2024 Jun:224:116261.|Diabetes. 2017 Aug;66 (8) :2201-2212. |Exp Anim. 2022 Nov 10;71 (4) :519-528.|Front Aging Neurosci. 2021 Feb 15:13:624387.|J Hepatol. 2022 Nov 9; S0168-8278 (22) 03285-8.|J Inflamm Res. 2021 Dec 18;14:7007-7019.|Metabolism. 2025 Apr 29:156275.|PLoS One. 2015 Nov 5;10 (11) :e0142087.|Redox Biol. 2019 Jan;20:75-86.|Res Sq. 2024 Aug 10.|Research Square Preprint. 2021 Nov.|Sci Rep. 2024 Nov 1;14 (1) :26346.|SSRN. 2025 Jun 2.|Blood. 2015 Jan 22;125 (4) :710-9.

• CAS Number:

  304462-19-9