UMB-32

• Description :

  UMB-32, a potent, selective BRD4 inhibitor, binds BRD4 with the Kd of 550 nM, and IC50 of 637 nM. UMB-32 also shows potency against TAF1, a bromodomain-containing transcription factor[1].

• UNSPSC :

  12352005

• Target :

  Epigenetic Reader Domain

• Type :

  Reference compound

• Related Pathways :

  Epigenetics

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/umb-32.html

• Purity :

  99.11

• Solubility :

  DMSO : 100 mg/mL (ultrasonic)

• Smiles :

  CC(C)(NC1=C(C2=CC=C(C=C2)C3=C(ON=C3C)C)N=C4N1C=CN=C4)C

• Molecular Formula :

  C21H23N5O

• Molecular Weight :

  361.44

• References & Citations :

  [1]Michael R McKeown, et al. Biased multicomponent reactions to develop novel bromodomain inhibitors. J Med Chem. 2014 Nov 13;57 (21) :9019-27.

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  -20°C, 3 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [1635437-39-6]