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Ppc-1

CAT: 0804-HY-117843Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-117843Size:1 Each
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Description
Ppc-1 is a mitochondrial uncoupler. Ppc-1 enhances mitochondrial oxygen consumption without adverse effects on ATP production. Ppc-1 is a cell-permeate interleukin-2 (IL-2) inhibitor. Ppc-1 inhibits the Gram-negative periodontopathogen Porphyromonas gingivalis. Ppc-1 has anti-obesity, antibacterial and anti-inflammatory activities[1][2][3][4].
CAS Number
1245818-17-0
UNSPSC
12352005
Target
Bacterial; Interleukin Related; Mitochondrial Metabolism
Type
Reference compound
Related Pathways
Anti-infection; Immunology/Inflammation; Metabolic Enzyme/Protease
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Infection; Metabolic Disease; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/ppc-1.html
Solubility
10 mM in DMSO
Smiles
O=C(C1=NC2=C(OC/C=C(C)/C)C=CC=C2C(OC)=C1)OC/C=C(C)\C
Molecular Formula
C21H25NO4
Molecular Weight
355.43
References & Citations
[1]Suzuki T, et al. Weight loss by Ppc-1, a novel small molecule mitochondrial uncoupler derived from slime mold. PLoS One. 2015 Feb 10;10 (2) :e0117088.|[2]Ogura M, et al. Prenylated quinolinecarboxylic acid derivative suppresses immune response through inhibition of PAK2. Biochem Pharmacol. 2016 Apr 1;105:55-65.|[3]Haruhisa Kikuchi a, et al. Novel prenylated and geranylated aromatic compounds isolated from Polysphondylium cellular slime molds. Tetrahedron 66 (2010) 6000-6007.|[4]Azelmat J, et al. Antibacterial and Anti-inflammatory Activities of Ppc-1, Active Principle of the Cellular Slime Mold Polysphondylium pseudo-candidum. Med Chem. 2015;11 (7) :666-9.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
IL-2

Chemical Information

3-Methylbut-2-enyl 4-methoxy-8-(3-methylbut-2-enoxy)quinoline-2-carboxylate

Ppc-1 has been reported in Heterostelium tenuissimum with data available.

CAS Number1245818-17-0
PubChem CID46910769
IUPAC Name3-methylbut-2-enyl 4-methoxy-8-(3-methylbut-2-enoxy)quinoline-2-carboxylate
Molecular FormulaC21H25NO4
Molecular Weight355.4
XLogP5.3
Topological Polar Surface Area57.7
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count5
Rotatable Bond Count8
Heavy Atom Count26
Formal Charge0
Complexity520
SMILES
CC(=CCOC1=CC=CC2=C1N=C(C=C2OC)C(=O)OCC=C(C)C)C
InChI
InChI=1S/C21H25NO4/c1-14(2)9-11-25-18-8-6-7-16-19(24-5)13-17(22-20(16)18)21(23)26-12-10-15(3)4/h6-10,13H,11-12H2,1-5H3
InChIKey
PBLQSFOIWOTFNY-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of 3-Methylbut-2-enyl 4-methoxy-8-(3-methylbut-2-enoxy)quinoline-2-carboxylate
CAS: 1245818-17-0
CID: 46910769
Formula: C21H25NO4
MW: 355.4
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight355.4
XLogP35.3
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count5
Rotatable Bond Count8
Exact Mass355.17835828
Monoisotopic Mass355.17835828
Topological Polar Surface Area57.7 Ų
Heavy Atom Count26
Formal Charge0
Complexity520
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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