PPC-NHS ester

• Description :

  PPC-NHS ester is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) [1].

• Product Name Alternative :

  2,5-Dioxopyrrolidin-1-yl 3- (pyridin-2-yldisulfanyl) butanoate

• UNSPSC :

  12352203

• Hazard Statement :

  H302, H315, H319, H335

• Target :

  ADC Linker

• Type :

  ADC Related

• Related Pathways :

  Antibody-drug Conjugate/ADC Related

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/ppc-nhs-ester.html

• Purity :

  98.0

• Solubility :

  DMSO : 100 mg/mL (ultrasonic)

• Smiles :

  CC(SSC1=NC=CC=C1)CC(ON2C(CCC2=O)=O)=O

• Molecular Formula :

  C13H14N2O4S2

• Molecular Weight :

  326.40

• Precautions :

  H302, H315, H319, H335

• References & Citations :

  [1]Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16 (5) :315-337.

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  -20°C, 3 years (Powder)

• Scientific Category :

  ADC Related

• Clinical Information :

  No Development Reported

• Isoform :

  Cleavable Linker; Disulfide Cleavable Linker

• CAS Number :

  [107348-47-0]