OSU-2S

• Description :

  OSU-2S is a potent PKCδ activator. OSU-2S inhibits cell proliferation and migration. OSU-2S decreases the expression of p-ERK1/2, increases the expression of PKCδ (38 kDa) when combined with Sorafenib (HY-10201) . OSU-2S induces Apoptosis. OSU-2S slao is a non-immunosuppressive analogue of FTY720. OSU-2S shows anticancer activity[1][2].

• UNSPSC :

  12352005

• Target :

  Apoptosis; PKC

• Type :

  Reference compound

• Related Pathways :

  Apoptosis; Epigenetics; TGF-beta/Smad

• Applications :

  Cancer-Kinase/protease

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/osu-2s.html

• Solubility :

  10 mM in DMSO

• Smiles :

  CCC[C@@](CCC1=CC=C(OCCCCCC(C)C)C=C1)(N)CO

• Molecular Formula :

  C21H37NO2

• Molecular Weight :

  335.52

• References & Citations :

  [1]Omar HA, et al. OSU-2S/Sorafenib Synergistic Antitumor Combination against Hepatocellular Carcinoma: The Role of PKCδ/p53. Front Pharmacol. 2016 Nov 30;7:463.|[2]Omar HA, et al. Antitumor effects of OSU-2S, a nonimmunosuppressive analogue of FTY720, in hepatocellular carcinoma. Hepatology. 2011 Jun;53 (6) :1943-58.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  PKCδ

• CAS Number :

  [1351056-65-9]