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OSU-T315

CAT: 0804-HY-18676-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-18676-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
OSU-T315 (ILK-IN-1) is a small Integrin-linked kinase (ILK) inhibitor with an IC50 of 0.6 μM, inhibiting PI3K/AKT signaling by dephosphorylation of AKT-Ser473 and other ILK targets (GSK-3β and myosin light chain) [1]. OSU-T315 abrogates AKT activation by impeding AKT localization in lipid rafts and triggers caspase-dependent apoptosis in an ILK-independent manner[2]. OSU-T315 causes cell death through apoptosis and autophagy[1].
CAS Number
2070015-22-2
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Apoptosis; Autophagy; Integrin
Type
Reference compound
Related Pathways
Apoptosis; Autophagy; Cytoskeleton
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ILK-IN-1.html
Purity
99.88
Solubility
DMSO : ≥ 260 mg/mL
Smiles
O=C(NC)CCC1=CC(C2=CC=C(C3=CC=C(C(F)(F)F)C=C3)C=C2)=NN1C4=CC=C(N5CCNCC5)C=C4
Molecular Formula
C30H30F3N5O
Molecular Weight
533.59
Precautions
H302, H315, H319, H335
References & Citations
[1]Su-Lin Lee, et al Identification and Characterization of a Novel Integrin-Linked Kinase Inhibitor.J Med Chem. 2011 Sep 22; 54 (18) : 6364–6374|[2]Liu TM, et al. OSU-T315: a novel targeted therapeutic that antagonizes AKT membrane localization and activation of chronic lymphocytic leukemia cells. Blood. 2015 Jan 8;125 (2) :284-95.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Chemical Information

Ilk-IN-2
CAS Number2070015-22-2
PubChem CID118986645
IUPAC NameN-methyl-3-[1-(4-piperazin-1-ylphenyl)-3-[4-[4-(trifluoromethyl)phenyl]phenyl]pyrazol-5-yl]propanamide
Molecular FormulaC30H30F3N5O
Molecular Weight533.6
XLogP5.1
Topological Polar Surface Area62.2
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count7
Rotatable Bond Count7
Heavy Atom Count39
Formal Charge0
Complexity767
SMILES
CNC(=O)CCC1=CC(=NN1C2=CC=C(C=C2)N3CCNCC3)C4=CC=C(C=C4)C5=CC=C(C=C5)C(F)(F)F
InChI
InChI=1S/C30H30F3N5O/c1-34-29(39)15-14-27-20-28(36-38(27)26-12-10-25(11-13-26)37-18-16-35-17-19-37)23-4-2-21(3-5-23)22-6-8-24(9-7-22)30(31,32)33/h2-13,20,35H,14-19H2,1H3,(H,34,39)
InChIKey
AJLOJUFSIDSBNN-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Ilk-IN-2
CAS: 2070015-22-2
CID: 118986645
Formula: C30H30F3N5O
MW: 533.6
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight533.6
XLogP35.1
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count7
Rotatable Bond Count7
Exact Mass533.24024508
Monoisotopic Mass533.24024508
Topological Polar Surface Area62.2 Ų
Heavy Atom Count39
Formal Charge0
Complexity767
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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Alternative Products

CatalogName
C12259-5mgOSU-T315
A20870-50OSU-T315 50mg
A20870-10OSU-T315 10mg
A20870-1OSU-T315 1mg
A20870-500OSU-T315 500mg
A20870-5OSU-T315 5mg
A20870-100OSU-T315 100mg
A20870-25OSU-T315 25mg
A20870-2OSU-T315 2mg
M20219-01OSU-T315 (15-regioisomer)

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