OSU-03013

• Description:

  OSU-03013 is a Celecoxib (HY-14398) analog. OSU-03013 can promote apoptosis, up-regulate E-cadherin, and down-regulate β-catenin, c-myc, Wnt1, and N-cadherin. OSU-03013 reduces cell migration and invasion. OSU-03013 regulates both Wnt and mTOR expression to inhibit colon cancer (CC) cell proliferation. OSU-03013 can be used for CC cancer research[1].

• UNSPSC:

  12352005

• Target:

  Apoptosis; Cadherin; c-Myc; mTOR; Wnt; β-catenin

• Related Pathways:

  Apoptosis; Cytoskeleton; PI3K/Akt/mTOR; Stem Cell/Wnt

• Field of Research:

  Cancer

• Smiles:

  NC(NC1=CC=C(N2N=C(C(F)(F)F)C=C2C3=CC=C4C5=CC=CC=C5C=CC4=C3)C=C1)=N

• Molecular Formula:

  C25H18F3N5

• Molecular Weight:

  445.44

• References & Citations:

  [1]Chunyong Y, et al. Mechanism of Inhibition of Growth and Metastasis of Colon Cancer by Celecoxib Analog OSU-03013 via Wnt Signaling Pathway. Acta Poloniae Pharmaceutica – Drug Research. 2023, 80 (6) : 929-937.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  742112-34-1