ROCK-IN-D2

• Description :

  ROCK-IN-D2 is a potent and selective ROCK inhibitor[1].

• CAS Number :

  [1219721-78-4]

• UNSPSC :

  12352005

• Target :

  ROCK

• Type :

  Reference compound

• Related Pathways :

  Cell Cycle/DNA Damage; Cytoskeleton; Stem Cell/Wnt; TGF-beta/Smad

• Applications :

  Cancer-Kinase/protease

• Field of Research :

  Others

• Assay Protocol :

  https://www.medchemexpress.com/rock-in-d2.html

• Solubility :

  10 mM in DMSO

• Smiles :

  O=C(NCC1=CC=CC=C1)NC2=C(C=C(C=C2)C3=CNN=C3)N(C)CCN(C)C

• Molecular Formula :

  C22H28N6O

• Molecular Weight :

  392.50

• References & Citations :

  [1]Ding Mei, et al. Discovery of potent and selective urea-based ROCK inhibitors: Exploring the inhibitor’s potency and ROCK2/PKA selectivity by 3D-QSAR, molecular docking and molecular dynamics simulations.Bioorg Med Chem. 2015 May 15;23 (10) :2505-17.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported