ROCK-IN-4

CAT: 0804-HY-151189Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-151189Size:1 Each
Selected
PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
Description
ROCK-IN-4 is a potent ROCK inhibitor maintaining NO releasing ability. ROCK-IN-4 reversibly depolymerizes F-actin, and suppresses mitochondrial respiration in human trabecular meshwork (HTM) cells. ROCK-IN-4 can be used for glaucoma or ocular hypertension research[1].
CAS Number
[2488395-07-7]
UNSPSC
12352005
Target
ROCK
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Cytoskeleton; Stem Cell/Wnt; TGF-beta/Smad
Applications
Cancer-Kinase/protease
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/rock-in-4.html
Solubility
10 mM in DMSO
Smiles
C[C@H]1CN(C(OCCCCO[N+]([O-])=O)=O)CCCN1S(=O)(C2=CC=CC3=C2C(F)=CN=C3)=O.[H]Cl
Molecular Formula
C20H26ClFN4O7S
Molecular Weight
520.96
References & Citations
[1]Yang Z, et al. Identification of Nitric Oxide-Donating Ripasudil Derivatives with Intraocular Pressure Lowering and Retinal Ganglion Cell Protection Activities. J Med Chem. 2022 Aug 25.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Related Products

CatalogName
HY-113641ROCK-IN-32
HY-176133ROCK-IN-12
HY-156593ROCK-IN-9
HY-153569ROCK-IN-7
HY-123484ROCK-IN-D1
HY-153564ROCK-IN-6
HY-156550ROCK-IN-8
HY-153011-01ROCK-IN-5
HY-10833-01ROCK-IN-10
HY-U00351-01ROCK-IN-1

Alternative Products

CatalogName
T63637-01ROCK-IN-4
1141100Rock And Rock Forming Mineral Collection
404217-01Rock-1
T204468-01ROCK-IN-11
MBS5810334ROCK-IN-5
T24724-01ROCK-IN-D2
1141080/6The Rock Box
333031-01Rock-2
T79080-01ROCK-IN-7
T79833-01ROCK-IN-9

Popular Products