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MAGL-IN-12

CAT: 0804-HY-116143Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-116143Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
SAR127303 is an orally active, selective, competitive monoacylglycerol lipase (MAGL) covalent inhibitor with IC50s of 3.8 nM and 29 nM for mouse and human MAGL, respectively. SAR127303 potently elevates hippocampal levels of 2-AG in mice. SAR127303 decreased long term potentiation (LTP) of CA1 synaptic transmission and acetylcholine release in the hippocampus. SAR127303 produces antinociceptive effects in assays of inflammatory and visceral pain. SAR127303 slows down epileptogenesis[1].
CAS Number
1352011-38-1
UNSPSC
12352005
Target
MAGL
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/magl-in-12.html
Solubility
10 mM in DMSO
Smiles
ClC1=CC=C(C=C1)S(NCC2CCN(CC2)C(OC(C(F)(F)F)C(F)(F)F)=O)(=O)=O
Molecular Formula
C16H17ClF6N2O4S
Molecular Weight
482.83
References & Citations
[1]Guy Griebel, et al. Selective blockade of the hydrolysis of the endocannabinoid 2-arachidonoylglycerol impairs learning and memory performance while producing antinociceptive activity in rodents. Sci Rep. 2015 Jan 6:5:7642.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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