CP 226269

CAT: 0804-HY-116082-01Size: 1 mgDry Ice: NoHazardous: No
CAT#:0804-HY-116082-01Size:1 mg
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Description
CP 226269 is a potent dopamine D4 receptor agonist that induces calcium flux with EC50 of 32 nM. CP 226269 stimulates phospholipid methylation (PLM) in SK-N-MC neuroblastoma cells with an EC50 of 2.9 nM. CP 226269 can be used in the research of schizophrenia and other related diseases[1][2][3].
CAS Number
[220941-93-5]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Dopamine Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/cp-226269.html
Purity
99.65
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
FC1=CC2=C(C=C1)NC(CN3CCN(CC3)C4=NC=CC=C4)=C2
Molecular Formula
C18H19FN4
Molecular Weight
310.37
Precautions
H302, H315, H319, H335
References & Citations
[1]Robert B Moreland, et al. Comparative pharmacology of human dopamine D (2) -like receptor stable cell lines coupled to calcium flux through Galpha (qo5) . Biochem Pharmacol. 2004 Aug 15;68 (4) :761-72. |[2]Sharma A, et al. D4 dopamine receptor-mediated phospholipid methylation and its implications for mental illnesses such as schizophrenia. Mol Psychiatry. 1999 May;4 (3) :235-46. |[3]Zhang K, et al. Role of dopamine D (4) receptors in motor hyperactivity induced by neonatal 6-hydroxydopamine lesions in rats. Neuropsychopharmacology. 2001 Nov;25 (5) :624-32.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
D4 Receptor

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