HDAC-IN-9

• Description :

  HDAC-IN-9 is a potent and selective tubulin and HDAC dual inhibitor. HDAC-IN-9 inhibits the invasion and migration of A549 cells. HDAC-IN-9 shows potent antitumor and antiangiogenic effect in vitro and in vivo[1].

• UNSPSC :

  12352005

• Target :

  Apoptosis; HDAC; Microtubule/Tubulin

• Type :

  Reference compound

• Related Pathways :

  Apoptosis; Cell Cycle/DNA Damage; Cytoskeleton; Epigenetics

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/hdac-in-9.html

• Solubility :

  10 mM in DMSO

• Smiles :

  [H][C@]12CC[C@@]3([C@H](CC[C@]3([C@@]1(CCC4=CC(OCC5=CC=C(C=C5)C(NC6=C(C=CC=C6)N)=O)=C(C=C42)OC)[H])[H])O)C

• Molecular Formula :

  C33H38N2O4

• Molecular Weight :

  526.67

• References & Citations :

  [1]Sun M, et al. 2-Methoxydiol derivatives as new tubulin and HDAC dual-targeting inhibitors, displaying antitumor and antiangiogenic response. Bioorg Chem. 2022; 120:105625.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  HDAC1; HDAC2; HDAC6; HDAC8