K783-0308

CAT: 0804-HY-115906Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-115906Size:1 Each
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Description
K783-0308 is a potent and selective dual inhibitor of FLT3 and MNK2 with IC50 values of 680 and 406 nM, respectively. K783-0308 inhibits the growth of MOLM-13 (IC50=10.5 μM) and MV-4-11 (IC50=10.4 μM) cells. K783-0308 promotes acute myeloid leukemia (AML) cell apoptosis and cell cycle arrests in the G0/G1 phase[1].
CAS Number
[422554-29-8]
UNSPSC
12352005
Target
Apoptosis; FLT3; MNK
Type
Reference compound
Related Pathways
Apoptosis; MAPK/ERK Pathway; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/k783-0308.html
Solubility
10 mM in DMSO
Smiles
O=C(C1=CC=C2C(N=CN2C3=CC=C(CC)C=C3)=C1)NC4CCCC4
Molecular Formula
C21H23N3O
Molecular Weight
333.43
References & Citations
[1]Yen SC, et al. Identification of a dual FLT3 and MNK2 inhibitor for acute myeloid leukemia treatment using a structure-based virtual screening approach. Bioorg Chem. 2022, 121:105675.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
MNK2

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