Mant-GTPγS

• UNSPSC Description:

  Mant-GTPγS, a GTP mimetic, is a potent competitive adenylyl cyclase (AC) inhibitor. Mant-GTPγS is a potent YdeH inhibitor[1][2][3].

• Target Antigen:

  Adenylate Cyclase

• Type:

  Reference compound

• Related Pathways:

  GPCR/G Protein

• Applications:

  Neuroscience-Neuromodulation

• Field of Research:

  Cardiovascular Disease

• Assay Protocol:

  https://www.medchemexpress.com/mant-gtpγs.html

• Purity:

  93.0

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C(C1=CC=CC=C1NC)[穄.O=C2C(N=CN3[C@H]4[C@H](O[R])[C@H](O[R])[C@@H](COP(OP(OP(O)(O)=S)(O)=O)(O)=O)O4)=C3N=C(N)N2.[or].[H]

• Molecular Weight:

  672.39

• References & Citations:

  [1]Andreas Gille, et al. 2'(3')-O-(N-methylanthraniloyl)-substituted GTP analogs: a novel class of potent competitive adenylyl cyclase inhibitors. J Biol Chem. 2003 Apr 11;278(15):12672-9.|[2]Tomoharu Kanie, et al. The CEP19-RABL2 GTPase Complex Binds IFT-B to Initiate Intraflagellar Transport at the Ciliary Base. Dev Cell. 2017 Jul 10;42(1):22-36.e12.|[3]Christian Spangler, et al. Interaction of the diguanylate cyclase YdeH of Escherichia coli with 2',(3')-substituted purine and pyrimidine nucleotides. J Pharmacol Exp Ther. 2011 Jan;336(1):234-41.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Solution, -20°C, 2 years

• Clinical Information:

  No Development Reported

• CAS Number:

  136749-24-1