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GTPγS (tetralithium)

CAT: 0804-HY-137677B-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-137677B-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
GTPγS (Guanosine 5'-[γ-thio]triphosphate) tetralithium is a G-protein activator that protects proteins from proteolytic degradation, stimulates GLUT4 translocation in a tyrosine kinase-dependent manner, stimulate phospholipases and induce actin polymerization. GTPγS tetralithium to couple with G- protein α, to study its effect on kinase activity. GTPγS tetralithium acts as a component of lysis buffer[1][2][3][4].
CAS Number
94825-44-2
Product Name Alternative
Guanosine 5'-[γ-thio]triphosphate (tetralithium)
UNSPSC
12352005
Hazard Statement
H315, H319, H335
Target
GLUT
Related Pathways
Membrane Transporter/Ion Channel
Field of Research
Others
Purity
96.04
Solubility
H2O : ≥ 100 mg/mL
Smiles
O[C@H]1[C@@H](O)[C@H](N2C(NC(N)=NC3=O)=C3N=C2)O[C@@H]1COP(OP(OP(S[Li])(O[Li])=O)(O[Li])=O)(O[Li])=O
Molecular Formula
C10H12Li4N5O13P3S
Molecular Weight
562.98
Precautions
H315, H319, H335
References & Citations
[1]Julie G Hensler, et al. Differential Regulation of 5-HT1A Receptor-G Protein Interactions in Brain Following Chronic Antidepressant Administration. Neuropsychopharmacology. 2002 May;26 (5) :565-73.|[2]Pilar Sánchez-Blázquez, et al. Brain-specific Galphaz interacts with Src tyrosine kinase to regulate Mu-opioid receptor-NMDAR signaling pathway. Cell Signal. 2009 Sep;21 (9) :1444-54.|[3]Xufeng Wu, et al. Rab27a is an essential component of melanosome receptor for myosin Va. Mol Biol Cell. 2002 May;13 (5) :1735-49.|[4]Li-Bin Liu, et al. Insulin recruits GLUT4 from distinct compartments via distinct traffic pathways with differential microtubule dependence in rat adipocytes. J Biol Chem. 2003 Aug 8;278 (32) :30157-69. doi: 10.1074/jbc.M301511200.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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