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12 (S) -HPEPE

CAT: 0804-HY-113913-01Size: 50 µgDry Ice: NoHazardous: No
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CAT#:0804-HY-113913-01Size:50 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
12 (S) -HPEPE is a lipoxygenase product and an intermediate metabolite that leads to downregulation of PGHS-2 and has potential anti-inflammatory activity. 12 (S) -HPEPE reduces interleukin 1h (IL-1h) -induced PGHS-2 expression in human lung microvascular endothelial cells[1].
CAS Number
103239-14-1
UNSPSC
12352211
Hazard Statement
H302-H315-H319-H335
Target
Prostaglandin Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/12-s-hpepe.html
Solubility
10 mM in DMSO
Smiles
CC/C=C\C/C=C\C[C@H](OO)/C=C/C=C\C/C=C\CCCC(O)=O
Molecular Formula
C20H30O4
Molecular Weight
334.45
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
References & Citations
[1]Ait-Said F, et al. Inhibition by eicosapentaenoic acid of IL-1beta-induced PGHS-2 expression in human microvascular endothelial cells: involvement of lipoxygenase-derived metabolites and p38 MAPK pathway. Biochim Biophys Acta. 2003 Feb 20;1631 (1) :77-84.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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