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12 (S) -HPETE

CAT: 0804-HY-113443Size: 50 µgDry Ice: NoHazardous: No
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CAT#:0804-HY-113443Size:50 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
12 (S) -HPETE is a 12-hydroxyeicosatetraenoic acid. 12 (S) -HPETE has the function of regulating vascular tone. 12 (S) -HPETE induces the expression of c-Fos and c-Jun protein and increases activating protein 1 (AP-1) activity in vascular smooth muscle cells.12 (S) -HPETE may play a physiological role in vasomotor regulation through endothelium itself and crosstalk between blood cells and endothelium. 12 (S) -HPETE can be used in the study of cerebrovascular tension[1][2].
CAS Number
71774-10-2
UNSPSC
12352211
Hazard Statement
H225, H319
Target
AP-1
Type
Reference compound
Related Pathways
Immunology/Inflammation
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/12-s-hpete.html
Solubility
10 mM in DMSO
Smiles
CCCCC/C=C\C[C@H](OO)/C=C/C=C\C/C=C\CCCC(O)=O
Molecular Formula
C20H32O4
Molecular Weight
336.47
Precautions
H225, H319
References & Citations
[1]Nishiyama M, et al. Endothelium is required for 12-hydroperoxyeicosatetraenoic acid-induced vasoconstriction. Eur J Pharmacol. 1998 Jan 2;341 (1) :57-63.|[2]Rao GN, et al. Role of hydroperoxyeicosatetraenoic acids in oxidative stress-induced activating protein 1 (AP-1) activity. J Biol Chem. 1996 Nov 1;271 (44) :27760-4.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, stored under nitrogen)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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