D-α-Hydroxyglutaric acid

• UNSPSC Description:

  D-α-Hydroxyglutaric acid ((R)-2-Hydroxyglutarate) is the principal metabolite accumulating in neurometabolic disease D-2-hydroxyglutaric aciduria. D-α-Hydroxyglutaric acid is a weak competitive antagonist of α-ketoglutarate (α-KG) and inhibits multiple α-KG-dependent dioxygenases with a Ki of 10.87 mM. D-α-Hydroxyglutaric acid increases reactive oxygen species (ROS) production. D-α-Hydroxyglutaric acid binds and inhibits ATP synthase and inhibits mTOR signaling[1][2][3][4][5].

• Target Antigen:

  ATP Synthase; Endogenous Metabolite; mTOR; Reactive Oxygen Species

• Type:

  Natural Products

• Related Pathways:

  Immunology/Inflammation;Membrane Transporter/Ion Channel;Metabolic Enzyme/Protease;NF-κB;PI3K/Akt/mTOR

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Cancer; Inflammation/Immunology; Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/d-α-hydroxyglutaric-acid.html

• Solubility:

  H2O : 200 mg/mL (ultrasonic)

• Smiles:

  O=C(O)[C@H](O)CCC(O)=O

• Molecular Weight:

  148.11

• References & Citations:

  [1]Xu W, et al. Oncometabolite 2-hydroxyglutarate is a competitive inhibitor of α-ketoglutarate-dependent dioxygenases. Cancer Cell. 2011 Jan 18;19(1):17-30.|[2]Fu X, et al. 2-Hydroxyglutarate Inhibits ATP Synthase and mTOR Signaling. Cell Metab. 2015 Sep 1;22(3):508-15.|[3]Martijn Kranendijk, et al. Progress in understanding 2-hydroxyglutaric acidurias. J Inherit Metab Dis. 2012 Jul;35(4):571-87.|[4]Martin Böttcher, et al. D-2-hydroxyglutarate interferes with HIF-1α stability skewing T-cell metabolism towards oxidative phosphorylation and impairing Th17 polarization. Oncoimmunology. 2018 Mar 26;7(7):e1445454.|[5]Alexandra Latini , et al. D-2-hydroxyglutaric acid induces oxidative stress in cerebral cortex of young rats. Eur J Neurosci. 2003 May;17(10):2017-22.Research Square Preprint. 2024 Apr 19.|Biosensors (Basel). 2022 Jan 25;12(2):66.|Research Square Preprint. 2024 Mar 20.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  13095-47-1