α-Hydroxyglutaric acid (disodium)

• UNSPSC Description:

  α-Hydroxyglutaric acid (2-Hydroxyglutarate) disodium is an α-hydroxy acid form of glutaric acid. α-Hydroxyglutaric acid disodium is a competitive inhibitor of multiple α-ketoglutarate-dependent dioxygenases, including histone demethylases and the TET family of 5-methlycytosine (5mC) hydroxylases[1].

• Target Antigen:

  Endogenous Metabolite; Histone Demethylase

• Type:

  Natural Products

• Related Pathways:

  Epigenetics;Metabolic Enzyme/Protease

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/α-hydroxyglutaric-acid-disodium.html

• Purity:

  98.0

• Solubility:

  H2O : 125 mg/mL (ultrasonic;warming;heat to 60°C)

• Smiles:

  O=C(O[Na])C(O)CCC(O[Na])=O

• Molecular Weight:

  192.08

• References & Citations:

  [1]Wei Xu, et al. Oncometabolite 2-hydroxyglutarate is a competitive inhibitor of α-ketoglutarate-dependent dioxygenases. Cancer Cell. 2011 Jan 18;19(1):17-30.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  -20°C (Powder, sealed storage, away from moisture)

• Clinical Information:

  No Development Reported

• CAS Number:

  40951-21-1