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α-Hydroxyglutaric acid (disodium)

CAT: 0804-HY-113038A-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-113038A-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
α-Hydroxyglutaric acid (2-Hydroxyglutarate) disodium is an α-hydroxy acid form of glutaric acid. α-Hydroxyglutaric acid disodium is a competitive inhibitor of multiple α-ketoglutarate-dependent dioxygenases, including histone demethylases and the TET family of 5-methlycytosine (5mC) hydroxylases[1].
CAS Number
40951-21-1
Product Name Alternative
2-Hydroxyglutarate (disodium) ; 2-Hydroxyglutaric acid (disodium) ; 2-Hydroxypentanedioic acid (disodium)
UNSPSC
12352211
Hazard Statement
H302, H312, H332
Target
Endogenous Metabolite; Histone Demethylase
Type
Natural Products
Related Pathways
Epigenetics; Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/α-hydroxyglutaric-acid-disodium.html
Purity
98.0
Solubility
H2O : 125 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C(O[Na])C(O)CCC(O[Na])=O
Molecular Formula
C5H6Na2O5
Molecular Weight
192.08
Precautions
H302, H312, H332
References & Citations
[1]Wei Xu, et al. Oncometabolite 2-hydroxyglutarate is a competitive inhibitor of α-ketoglutarate-dependent dioxygenases. Cancer Cell. 2011 Jan 18;19 (1) :17-30.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
Human Endogenous Metabolite; Microbial Metabolite

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