α-Hydroxyglutaric acid

• UNSPSC Description:

  α-Hydroxyglutaric acid (2-Hydroxyglutarate) is an α-hydroxy acid form of glutaric acid. α-Hydroxyglutaric acid is a competitive inhibitor of multiple α-ketoglutarate-dependent dioxygenases, including histone demethylases and the TET family of 5-methlycytosine (5mC) hydroxylases[1].

• Target Antigen:

  Endogenous Metabolite; Histone Demethylase

• Type:

  Reference compound

• Related Pathways:

  Epigenetics;Metabolic Enzyme/Protease

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/α-hydroxyglutaric-acid.html

• Purity:

  99.0

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C(O)C(O)CCC(O)=O

• Molecular Weight:

  148.11

• References & Citations:

  [1]Wei Xu, et al. Oncometabolite 2-hydroxyglutarate is a competitive inhibitor of α-ketoglutarate-dependent dioxygenases. Cancer Cell. 2011 Jan 18;19(1):17-30.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Solution, -20°C, 2 years

• Clinical Information:

  No Development Reported

• CAS Number:

  2889-31-8