α-Hydroxyglutaric acid

• Description:

  α-Hydroxyglutaric acid (2-Hydroxyglutarate) is an α-hydroxy acid form of glutaric acid. α-Hydroxyglutaric acid is a competitive inhibitor of multiple α-ketoglutarate-dependent dioxygenases, including histone demethylases and the TET family of 5-methlycytosine (5mC) hydroxylases[1].

• Product Name Alternative:

  2-Hydroxyglutarate; 2-Hydroxyglutaric acid; 2-Hydroxypentanedioic acid

• UNSPSC:

  12352211

• Hazard Statement:

  H302, H312, H332

• Target:

  Endogenous Metabolite; Histone Demethylase

• Type:

  Reference compound

• Related Pathways:

  Epigenetics; Metabolic Enzyme/Protease

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/α-hydroxyglutaric-acid.html

• Concentration:

  67.52 mM * 0.5mL in Ethanol

• Purity:

  99.0

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C(O)C(O)CCC(O)=O

• Molecular Formula:

  C5H8O5

• Molecular Weight:

  148.11

• Precautions:

  H302, H312, H332

• References & Citations:

  [1]Wei Xu, et al. Oncometabolite 2-hydroxyglutarate is a competitive inhibitor of α-ketoglutarate-dependent dioxygenases. Cancer Cell. 2011 Jan 18;19 (1) :17-30.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Solution, -20°C, 2 years

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  Human Endogenous Metabolite; Microbial Metabolite

• CAS Number:

  [2889-31-8]