NCD38 (TFA)

• Description:

  NCD38 TFA is a LSD1-selective inhibitor[1][2].

• UNSPSC:

  12352005

• Target:

  Histone Demethylase

• Type:

  Reference compound

• Related Pathways:

  Epigenetics

• Field of Research:

  Others

• Assay Protocol:

  https://www.medchemexpress.com/ncd38-tfa.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C(C1=CC=C(C2=CC=CC=C2)C=C1)N[C@H](C(NCC3=CC=CC(Cl)=C3)=O)CCCCN[C@H]4[C@H](C5=CC=CC=C5)C4.O=C(O)C(F)(F)F

• Molecular Formula:

  C37H37ClF3N3O4

• Molecular Weight:

  680.16

• References & Citations:

  [1]G R Sareddy, et al. Novel KDM1A inhibitors induce differentiation and apoptosis of glioma stem cells via unfolded protein response pathway. Oncogene. 2017 Apr 27;36 (17) :2423-2434.|[2]Yosuke Ota , et al. Design, synthesis and evaluation of γ-turn mimetics as LSD1-selective inhibitors. Bioorg Med Chem. 2018 Feb 1;26 (3) :775-785.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported