MK-0736

• Description :

  MK-0736 (Compounds 1) is highly potent and selective inhibitor of 11β-HSD1. MK-0736 can be used for the research of type 2 diabetes, hypertension and metabolic syndrome[1].

• UNSPSC :

  12352005

• Target :

  11β-HSD

• Type :

  Reference compound

• Related Pathways :

  Metabolic Enzyme/Protease

• Applications :

  Metabolism-protein/nucleotide metabolism

• Field of Research :

  Metabolic Disease; Cardiovascular Disease

• Assay Protocol :

  https://www.medchemexpress.com/MK-0736.html

• Solubility :

  10 mM in DMSO

• Smiles :

  FC(C1=CC=CC=C1C2=NN=C(C3(CC4)CCC4(CCCS(=O)(CC)=O)CC3)N2C)(F)F

• Molecular Formula :

  C23H30F3N3O2S

• Molecular Weight :

  469.56

• References & Citations :

  [1]Sukrut Shah, et al. Efficacy and safety of the selective 11β-HSD-1 inhibitors MK-0736 and MK-0916 in overweight and obese patients with hypertension. J Am Soc Hypertens. 2011 May-Jun;5 (3) :166-76. |[2]Bauman DR, et al. Evaluation of selective inhibitors of 11β-HSD1 for the treatment of hypertension. Bioorg Med Chem Lett. 2013 Jun 15;23 (12) :3650-3.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  Phase 2

• CAS Number :

  [719272-79-4]