PI3Kγ inhibitor 7

• UNSPSC Description:

  PI3Kγ inhibitor 7 (compound 2) is a potent and orally active PI3Kγ inhibitor with IC50 values of 4768, 878.1, 3.42, 355.2 nM for PI3Kα, PI3Kβ, PI3Kγ, PI3Kδ, respectively. PI3Kγ inhibitor 7 shows antitumor activity[1]. PI3Kγ inhibitor 7 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

• Target Antigen:

  PI3K

• Type:

  Reference compound

• Related Pathways:

  PI3K/Akt/mTOR

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/pi3kγ-inhibitor-7.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C1C2=C(C#CC3=CN(C4CC4)N=C3)C=CC=C2N=C(N1C5=CC=CC=C5)[C@H](C)NC(C6=C7N(C=CC=N7)N=C6N)=O

• Molecular Weight:

  555.59

• References & Citations:

  [1]HeJun Lv, et al. Alkyne derivative, preparation method for same, and uses thereof. WO2021004421A1.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  2575863-25-9