ATRA-hydroxyimino

• UNSPSC Description:

  ATRA-hydroxyimino (CRABP-II ligand 1), the Retinoic acid (ATRA)-based moiety, binds to cIAP1 ligand (Bestatin) via a linker to form SNIPER to degrade CRABP-II in IMR-32 cells[1].

• Target Antigen:

  Ligands for Target Protein for PROTAC

• Type:

  Reference compound

• Related Pathways:

  PROTAC

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/crabp-ii-ligand-1.html

• Solubility:

  10 mM in DMSO

• Smiles:

  CC1=C(/C=C/C(C)=C/C=C/C(C)=C/C(O)=O)C(C)(C)CC/C1=N\O

• Molecular Weight:

  329.43

• References & Citations:

  [1]Scheepstra M, et al. Bivalent Ligands for Protein Degradation in Drug Discovery. Comput Struct Biotechnol J. 2019 Jan 25;17:160-176.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  135325-47-2