ATRA-hydroxyimino

• Description :

  ATRA-hydroxyimino (CRABP-II ligand 1), the Retinoic acid (ATRA) -based moiety, binds to cIAP1 ligand (Bestatin) via a linker to form SNIPER to degrade CRABP-II in IMR-32 cells[1].

• Product Name Alternative :

  CRABP-II ligand 1

• UNSPSC :

  12352211

• Target :

  Ligands for Target Protein for PROTAC

• Type :

  Reference compound

• Related Pathways :

  PROTAC

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/crabp-ii-ligand-1.html

• Solubility :

  10 mM in DMSO

• Smiles :

  CC1=C(/C=C/C(C)=C/C=C/C(C)=C/C(O)=O)C(C)(C)CC/C1=N\O

• Molecular Formula :

  C20H27NO3

• Molecular Weight :

  329.43

• References & Citations :

  [1]Scheepstra M, et al. Bivalent Ligands for Protein Degradation in Drug Discovery. Comput Struct Biotechnol J. 2019 Jan 25;17:160-176.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [135325-47-2]